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Endocrine and Thyroid Cancer NGS Panels


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Some risk factors for thyroid cancer are radiation exposure or low iodine diets. Alteration in the RET oncogene can be associated with higher risk of developing thyroid cancer (Source: cancer.net). 

This page introduces different NGS panel that are targeting different genes related to elevated risk for the development of thyroid cancer. Some of these genes are the AIP, PTEN, RET and the TP53 genes. 

For more information on additional genes included in the tests please contact the corresponding test provider, general information on thyroid cancer are available on this website.


 

Endocrine Cancer (see also Thyroid Cancer) 

Hereditary Endocrine Cancer

Targeted genes RET, MEN1, NTRK1

Source: Mendelics

Endocrine Hereditary Cancer Panel

Sequencing and Deletion/Duplication, 13 Genes
Source: Arup Laboratories

Multiple endocrine neoplasias /paraganglioma/pheochromocytoma panel

tested genes CDKN1B, MAX, MEN1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, VHL

Source: Centogene

Pheochromozytoma-Paraganglioma syndrome

Multi Gene Panel (11 Genes)
Targeted genes: MAX MEN1 NF1 PRKAR1A RET SDHAF2 SDHB SDHC SDHD TMEM127 VHL
Source: Medical Genetics Center


Thyroid Cancer

Endocrine Cancer: Sequencing Panel

Thyroid cancer is divided into several subcategories: (1) differentiated (follicular, papillary and Hurthle); (2) medullary; and (3) anaplastic (aggressive undifferentiated tumor). Medullary thyroid cancer (MTC) develops from the "C" or parafollicular cells of the thyroid gland which produce calcitonin. Approximately 80% of the cases of MTC are sporadic. The remaining inherited syndromes include multiple endocrine neoplasia (MEN) type 2A (also known as MEN 2A), MEN 2B, and familial MTC (FMTC). All three of these subtypes, MEN 2A, MEN 2B and FMTC, are inherited in an autosomal dominant pattern and involve an elevated risk for the development of medullary carcinoma of the thyroid.
Targeted genes: (15) AIP, CDC73, CDKN1B, MAX, MEN1, PRKAR1A, PTEN, RET, SDHAF2, SDHB, SDHC, SDHD, TMEM127, TP53, VHL
Source: Emory Genetics Laboratory

Invitae Thyroid Cancer Panel

The Invitae Thyroid Cancer Panel analyzes up to 11 genes that are associated with an increased lifetime risk of developing thyroid cancer. These genes were selected based on the available evidence to date to provide Invitae’s most comprehensive hereditary thyroid cancer panel. Many of these genes are also associated with an increased risk of other types of cancer.
In addition to the primary panel, clinicians can also choose to include genes that have limited evidence of association with hereditary thyroid cancer.
Source: Invitae

Thyroid Cancer

Multi Gene Panel (13 Genes)
Targeted genes: APC ATM CHEK2 DICER1 FLCN MEN1 MUTYH PTEN RET SDHB SDHC SDHD STK11
Source: Medical Genetics Center

Thyroid Cancer NGS Panel

Targeted Genes: BRAF, HRAS, KRAS, MUTYH, NRAS, PTEN, RET, SDHB, SDHD, TP53
Source: Fulgent Diagnostics

Thyroid cancer panel, targeted

Tested genes APC, PTEN, RET

Source: Centogene

THYREON-PREDICT™

enetic testing of cold nodules of the thyroid gland at PentaCore Laboratory!
With the aid of the modern diagnostic tools, thyroid nodules can be found in 25-50% of the population. Among the so called “cold” nodules (which do not accumulate radioiodine, i.e. not working), 5-10% are susceptible to malignant transformation. Until now, we were not able to predict which nodule has a greater chance for becoming malignant. The genetic testing developed by the PentaCore Laboratory, at Semmelweis University, Budapest, Hungary, analyzes 10 different genes.

Source: Pentacorelab


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